Originally posted by lxh623 at 2009-4-12 10:48:
麻烦您一下,可能我的表述不十分清楚。
有个问题:
UNITED STATES OF AMERICA (US)
PATENT (Number; Kind; Date): United States of America (US)
开始部分完全与之一 ...
这是处理你贴出的数据的结果,你指一下看哪里还有问问题
- BASIC-PATENT:
- UNITED STATES OF AMERICA (US)
- PATENT (Number; Kind; Date): United States of America (US) 5,958,446; A; September 28, 1999
- TITLE: SOLUBILITY PARAMETER BASED DRUG DELIVERY SYSTEM AND METHOD FOR ALTERING DRUG SATURATION CONCENTRATION
- INVENTOR: MIRANDA JESUS, United States of America (US); SABLOTSKY STEVEN, United States of America (US)
- PRIORITY (Number; Kind; Date):
- United States of America (US) 1995-433754; A; May 04, 1995
- United States of America (US) 1991-722342; A1; June 27, 1991
- United States of America (US) 1989-295847; A2; January 11, 1989
- United States of America (US) 1988-164482; A2; March 04, 1988
- United States of America (US) 1991-671709; A2; April 02, 1991
- World Intellectual Property Organisation (WO) 1990US9001750; W; March 28, 1990
- PATENT ASSIGNEE: NOVEN PHARMA, United States of America (US)
- APPLICATION (Number; Kind; Date): United States of America (US) 1995433754; A; May 04, 1995
- INT-CL: A61F13/02 (Section A, Class 61, Sub-class F, Group 13, Sub-group 02)
- NAT-CL: 424448; X426449
- EURO-CL: A61F13/02M; A61K9/70E; A61L15/18; A61L15/58; A61L15/58M+C08L33/00; A61L15/58M+C08L31/04
- DERWENT NUMBER: C1989-106432; C1990-225696; C1991-230072; C1991-310376; C1993-036110; C1994-109332; C1995-044946; C1997-558092
- CHEMICAL ABSTRACT NUMBER: 111(10)084137W; 114(04)030158X; 116(10)091389M; 118(16)154566F; 120(26)331144F; 128(15)184708C
- ABST:
- The method of adjusting the saturation concentration of a drug in a transdermal composition for application to the dermis, which comprises mixing polymers having differing solubility parameters, so as to modulate the delivery of the drug. This results in the ability to achieve a predetermined permeation rate of the drug into and through the dermis. In one embodiment, a dermal composition of the present invention comprises a drug, an acrylate polymer, and a polysiloxane. The dermal compositions can be produced by a variety of methods known in the preparation of drug-containing adhesive preparations, including the mixing of the polymers, drug, and additional ingredients in solution, followed by removal of the processing solvents. The method and composition of this invention permit selectable loading of the drug into the dermal formulation and adjustment of the delivery rate of the drug from the composition through the dermis, while maintaining acceptable shear, tack, and peel adhesive properties.
- PATENT (Number; Kind; Date): United States of America (US) 5,300,291; A; April 05, 1994
- PATENT (Number; Kind; Date): World Intellectual Property Organisation (WO) 9,640,086; A3; February 13, 1997

