The elder upstairs, I don't quite understand what you mean.
My main purpose of this immunity package is to prevent getting poisoned, not to facilitate antivirus after being poisoned.
As for whether adding registry defense will make the registry bloated and affect the machine performance, I think it should not.
Because there are very few registry entries, unless it is a malignant full-disk infection type like Panda. And for empty folders, I think it should not affect the system performance either.